Dosage in continuous renal replacement therapy (CRRT) has been assessed in multiple randomized controlled trials and two meta-analyses. Results from these studies indicate that higher intensity dialysis did not result in improved survival or clinical benefits.

The 2012 KDIGO guideline recommends delivering an effluent volume of 20 to 25 mL/kg per hour. It also notes that this generally requires prescription of a higher effluent volume to achieve the targeted dose of therapy.

References

KDIGO clinical practice guidelines for acute kidney injury
Kidney Int Suppl. 2012;2(1)

Bouman CS, Oudemans-Van Straaten HM, Tijssen JG, Zandstra DF, Kesecioglu J
Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial.
Crit Care Med. 2002;30(10):2205.

Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, La Greca G
Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial.
Lancet. 2000;356(9223):26.

Saudan P, Niederberger M, De Seigneux S, Romand J, Pugin J, Perneger T, Martin PY
Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure.
Kidney Int. 2006;70(7):1312.

Tolwani AJ, Campbell RC, Stofan BS, Lai KR, Oster RA, Wille KM
Standard versus high-dose CVVHDF for ICU-related acute renal failure.
J Am Soc Nephrol. 2008;19(6):1233.

Jun M, Heerspink HJ, Ninomiya T, Gallagher M, Bellomo R, Myburgh J, Finfer S, Palevsky PM, Kellum JA, Perkovic V, Cass A
Intensities of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis.
Clin J Am Soc Nephrol. 2010;5(6):956.

Van Wert R, Friedrich JO, Scales DC, Wald R, Adhikari NK, University of Toronto Acute Kidney Injury Research Group
High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis.
Crit Care Med. 2010;38(5):1360.